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The synergistic premise is based on complementary mechanisms observed in separate studies, not on direct combination studies

Calcium is needed for the growth of healthy bones and teeth, muscle and heart action, nerve conduction, enzyme action and the normal functioning of glands

For example, melatonin can attenuate the injury by regulating classical ferroptosis pathway such as the p53 signaling pathway, the PI3K/AKT/mTOR signaling pathway, the Nrf2/HO-1 signaling pathway, and the ACSL4/CYP1B1 signaling pathway to suppress ferroptosis in these injury models (137140)

In addition, children and adolescents are prone to direct hand-to-mouth contact after touching textiles, toys, or the ground containing PFAS, thus leading to the increased ingestion of PFAS into the digestive tract

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