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GPX4 extends this chemistry to phospholipid hydroperoxides and helps limit iron-dependent lipid peroxidation and ferroptosis (Jiang et al., 2021)

Disabling CBP/p300-binding to NRF2 broadly attenuated NRF2 transcriptional activity resulting in an altered metabolic (depletion of glutathione) and lipidomic (specific depletion of triglycerides) cellular landscape

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