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98 SebecicB.NikolicV.SikiricP.SeiwerthS.SosaT.PatrljL.et al (1999)

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Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications

The resulting elevated concentrations of homocysteine and MMA are often found in patients with low serum vitamin B 12 and can usually be lowered with successful vitamin B 12 replacement therapy