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These findings indicate that liraglutide, semaglutide, and tirzepatide were each associated with significant improvements in liver enzyme levels over the 36-week treatment period, without evidence of differential effects between agents (Table 6 and Figure 4)

We collected a small cryo-EM dataset on this mutant in the presence of activating Ca 2+ , caffeine, and atorvastatin, which yielded both open ( ~ 3.4 ) and closed ( ~ 4.1 ) structures like wild-type RyR1 under the same experimental conditions (Fig

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