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REFERENCES USED AS SOURCES FOR THIS PAGE: 1 Vitamin B12 injection via Cleveland Clinic

Deficiencies can occur with medical conditions such as atrophic gastritis (which causes thinning of the stomach lining), pernicious anaemia, Crohns disease, celiac disease, lupus, or other immune system disorders and certain medications

That said, although side effects from vitamin B12 supplementation are very rare, it can possibly occur with B12 injections, but not with oral supplements

Methylation reactions are essential for the metabolism of components of the myelin sheath of nerve cells, as well as for synthesis and metabolism of neurotransmitters (22)

It must come from diet or supplementation