does semaglutide or tirzepatide have more side effects caused roughly half as many patients to stop treatment because of gastrointestinal as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Tirzepatide vs. Semaglutide: Key Differences

Efficacy and safety of sitagliptin/metformin fixed-dose combination compared with glimepiride in patients with type 2 diabetes: A multicenter randomized double-blind study

Clinical trials reveal that semaglutide not only enhances glycemic control but also significantly aids in weight reduction, an area where many of its peers struggle to show pronounced results

PMCID: PMC9775659.

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Prediabetes Two studies (one with liraglutide 31 and one with semaglutide 35 ) were specifically designed for patients affected by overweight/obesity and prediabetes, and two more studies (one with orlistat 32 and one with tirzepatide 36 ) reported a longer-term analysis on a subgroup of patients with prediabetes