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That phrase has a specific regulatory meaning

Curr Alzheimer Res 2005, 2:377-385

In an observational study including 147 subjects were administered single-daily dose of various DPP-4 inhibitors like alogliptin (12.5 or 25 mg), teneligliptin (10 or 20 mg), and sitagliptin (25 or 50 mg) for 3 months

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