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Ethics approval and informed consent This study was approved by Institutional Review Board of University of California San Francisco

A recent data science evidence-based approach to determine the top ten ingredients in oral skin supplements (from 71,000 dietary ingredients of which 1781 were found to have at least one skin-related publication assessed in human clinical trials) found that collagen had the most published human skin health-related data, followed by specific antioxidants (especially from natural sources or products) [25]

Use of this medicine may cause nausea, diarrhea, vomiting, dizziness, and hypotension

The GH/IGF-1 axis declines with age, and secretagogues can transiently raise it, but restoring a biomarker toward youthful levels has never been shown to equal restored youthful function and some GH-axis interventions carry theoretical risks that make the anti-aging framing particularly premature