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doi: 10.1016/B978-0-12-024911-4.50008-8 125 JiAWroblewskiJMCaiLde BeerMCWebbNRvan der WesthuyzenDR

Aune D, Keum N, Giovannucci E, Fadnes LT, Boffetta P, Greenwood DC, Tonstad S, Vatten LJ, Riboli E, Norat T

Expert Clinical Visual Grading: An independent trained evaluator assessed hyperpigmentation severity and skin tone evenness under standardised conditions at both timepoints, using a validated PCR clinical grading scale

Moderate deficiency may include obvious macrocytic anemia, glossitis, as well as some mild or subtle neurological features, such as distal sensory impairment.[] Severe deficiency is characterized by bone marrow suppression, neurological features, and the risk of cardiomyopathy

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