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Immunofluorescence staining was conducted to assess antioxidant capacity via SOD expression and to evaluate macrophage polarization using CD86 (M1 marker) and CD206 (M2 marker)
Nowadays, FOXO4-DRI studies are focused on the following aspects: osteoarthritis (senescent chondrocyte clearance), metabolic dysfunction (insulin resistance and obesity-associated senescence), neurodegeneration (eliminating senescent brain cells), and fibrotic diseases (idiopathic pulmonary and liver fibrosis)
B12 supports hematologic and neurologic functions, and L-carnitine transports long-chain fatty acids into mitochondria
However, their activity is reported to decrease with age, which is one of the risk factors for cataracts
