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As the weight came off, some felt more motivated to exercise, more at ease being seen in public, more able to build routines that had long felt out of reach

The concomitant improvement in insulin sensitivity and beta-cell function, which were associated with normalization of glucose levels in people with prediabetes, suggests that tirzepatide treatment may delay and potentially halt progression to T2D, by inducing so-called beta-cell rest and ultimately, modifying the natural history of prediabetes/T2D