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In vivo and in vitro enhanced tumoricidal effects of metformin, active vitamin D3, and 5-fluorouracil triple therapy against colon cancer by modulating the PI3K/Akt/PTEN/mTOR network

Macrophages are characterized by their ability to respond to environmental changes and can differentiate into two distinct subpopulations: pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages (Smigiel and Parks, 2018)

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