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Concomitant ICV administration of GLP- 1 and GIP significantly reduced food intake, body weight, and alcohol consumption
Each receptorGLP-1, GIP, and glucagonpossesses its own binding characteristics and downstream signaling pathways
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HR = 0.90 (125)], even in those patients with previous heart failure (132134), suggesting that the increased risk with saxagliptin is not mechanistically related to the inhibition of DPP-4 per se , but the cause is still unexplained
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