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Nauck et al., 2021a)
P., Muchowski, P
For example, a 5mg vial reconstituted to 2mg/ml requires 2.5ml of bacteriostatic water
These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +
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