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Splicing occurs through XBP1 mRNA to the translation of sXBP1 protein, which is a transcription factor that induces genes involved in chaperoning proteins and degrades misfolded proteins in ER, thus triggering inflammatory reaction and promoting cell apoptosis mediated by apoptosis ASK1 and JNK [99, 102]
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The highest retatrutide dose produced the biggest number in the Phase 3 TRIUMPH-1 trial: an average body-weight reduction of 28.3% at 80 weeks
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