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Sinha N, Whelan EC, Tobias JW, Avarbock M, Stefanovski D, Brinster RL (2021) Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse

Discontinuation and weight regain How often people stop the medication TRIUMPH-4 (n=445, 68 weeks, obesity with knee osteoarthritis): 18.2% on 12 mg, 12.2% on 9 mg, 4% on placebo 2 TRANSCEND-T2D-1 (n=537, 40 weeks, type 2 diabetes): 5.1% on 12 mg, 4.5% on 9 mg, 0% on placebo 3 Phase 2 (n=338, 48 weeks): 6 to 16% across doses, 1% on placebo 1 For comparison, Wegovys STEP-1 trial reported a discontinuation rate of around 7% due to side effects, and Mounjaros SURMOUNT-1 reported a similar rate

If early-phase trials show promise, pivotal phase 3 studies could begin within the next few years, potentially leading to regulatory submissions later in the decade

Chronically sun-damaged melanomas express low levels of nuclear glutathione-S-transferase-pi: an epidemiological and clinicopathological study in Italy

GR activity was expressed as nmol NADPH min 1 mg 1 protein