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Native Americans were chewing on the bark of the white willow for pain relief and fever reduction long before the barks salicin led to the invention (and, later, FDA approval) of aspirin
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IFN- binding to its receptor activates the downstream Janus Kinase (JAK)-STAT pathway, resulting in the phosphorylation of STAT1 (p-STAT1) (Miyazawa and Miyazono, 2017)