Scientific References: Dou Y, Lee A, Zhu L, Morton J, Ladiges W., Aging Pathobiology and Therapeutics , 2020
In preclinical models, its applied to cultured fibroblasts, epithelial tissues, and immune cells to study telomere dynamics, cell-cycle checkpoints, and oxidative-stress defensesall key processes in cellular aging
The information on the relevant siRNA sequence is provided below
Like other small peptides, glutathione is degraded by various peptidases including tripeptide aminopeptidases and -glutamyl transpeptidases 1,3
Given that NACA was able to counteract the effects of the ACOX1 gain-of-function mutation, antioxidant treatment was considered for patient#1 during a severe disease flare