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L-citrulline supplementation Rationale Oral L-arginine undergoes first-pass metabolism [38% in humans (Castillo et al., 1993)], whereas L-citrulline is converted into L-arginine via the argininosuccinate pathway, in which argininosuccinate synthase (ASS) catalyzes the formation of argininosuccinate from citrulline and aspartate

The hormonal drivers of appetite and weight gain that these medications address do not resolve simply because weight has been lost

References Bendotti, G., Montefusco, L., Lunati, M

Researchers also suggested that endocrine and metabolic changes beyond weight loss could contribute, although further investigation is required

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