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Phenomenological features of IVD degeneration and facet joint osteoarthritis have considerable overlap, including the destruction of cartilage and other joint tissues, subchondral bone changes, osteophyte formation and reduced joint space
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However, when the cell detects an apoptotic stimulus, such as DNA damage or metabolic stress, the intrinsic apoptotic pathway is triggered and mitochondrial cytochrome c is released into the cytosol ( c and then its translocation through permeabilized OMM
These side-effects are possible, but do not always occur
