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Research Background & Mechanistic Focus Current research use centers on coordinated cytoskeletal, cellular-migration, and structural-response signaling models, comparative presentation or formulation behavior where applicable, and controlled experimental models designed to evaluate compound-specific signaling activity within non-clinical laboratory systems
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Orexin receptor antagonistsdrugs that inhibit the wake-promoting activity of orexinshave shown remarkable success in promoting sleep
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This perspective is reinforced by the central gain model of tinnitus, which suggests that tinnitus results from an abnormal compensatory increase in gain (i.e., neural amplification) within the CAS to compensate for a loss of sensory input from the cochlea 9,10,11
