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J Thorac Dis 12(5):1952-1959, 2020

Similarly, alterations in IGF-1 signaling may impact neurogenesis and neuronal survival, thereby affecting mood and cognitive functions [97]

The muscle-to-fat loss ratio with GLP-1s isn't categorically different from non-pharmacologic weight loss

Combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the weight loss and cardiometabolic benefits of GLP-1 RA [21]

This can be thought of as making delivery trucks that carry glucose to cells work more efficiently