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It targets the GLP-1 receptor exclusively, producing average weight loss of 15 to 17 percent of body weight over 68 weeks in clinical trials

Diet plays one of the most significant roles in stimulating GLP-1 naturally

Over time, obese patients lose roughly 12% of their body weight on Wegovy (semaglutide) and about 18% on Zepbound (tirzepatide, which targets GLP-1 and another gut hormone, GIP.) Diana Thiara, MD, medical director of the UCSF Weight Management Program, says the results can be amazing and life-changing for people with obesity, a condition linked to a host of health risks

The most well-known is orlistat , available as Xenical (prescription) and Alli (over-the-counter)

Does Ozempic (Semaglutide) cause Weight Loss