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Common Side Effects of Tirzepatide and Semaglutide The most frequently reported side effects include: Nausea (particularly during dose increases) Diarrhea or constipation Vomiting Abdominal discomfort Decreased appetite (expected effect) Most side effects occur during dose escalation and typically improve within 4-8 weeks as your body adjusts to the medication

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Purchases through TrumpRx will not go through insurance, but will instead be out-of-pocket purchases, so price advantages and disadvantages will vary depending on insurance coverage (Lupkin, 2025) Pfizer, Eli Lily, AstraZeneca, and Novo Nordisk have already negotiated prices for medications to be made available via the TrumpRx website, and the Trump administration has stated it will continue to expand negotiations with manufacturers (The United States Government, 2025b, 2025c)