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GLP-1RAs are attractive candidates for the treatment of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) because they can reduce body weight and improve insulin secretion [77]

A similar scenario has in fact been reported recently in an alcoholic liver disease model in which long-term alcohol consumption activated NF-B in Kupffer cells, whereas NF-B activation in hepatocytes was inhibited 45

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In fact, research presented at the American Society for Metabolic and Bariatric Surgerys 2024 annual meeting shows that lifestyle changes alone are not as effective at promoting sustainable weight loss compared to GLP-1 agonist medications (8)