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These sorts of ideas would help to ensure that large-scale access can be targeted to those who would most benefit (rather than those who are easiest to reach) whether in populous countries (where the largest health gains are to be found) or countries with extremely high rates of obesity like small island developing states (where the most transformative changes in disease prevalence could be achieved)
The program included weekly follow ups and very gradual dose increases, which helped keep side effects minimal and made the process feel safe and well monitored
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Depending on the molecular properties (33), these agonists exert their effects by activating GLP-1R + glutamatergic neuronal populations (70, 71), but not GABAergic neurons (72)
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