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I think well see more patients coming into primary care whove been using compounded GLP-1s from med spas or online sources, says Nebraska Medicine bariatric surgeon Cori McBride, MD

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The human results are mixed, with small open-label studies encouraging but the controlled phase 2 OVERTURE trial missing its primary endpoint, and the larger pivotal trial has finished enrolling with results pending, so for now it is best read as mechanistically promising and clinically unproven

Aug 2020;53(4):515-529

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