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Peptides were then separated using a 60-min stepped gradient: 045% of buffer B for 70 min (buffer A: 95%/5%: H 2 O/DMSO + 0.1% FA

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10.1016/j.tips.2009.08.003 195 YoshidaT.AkahoshiF.SakashitaH.KitajimaH.NakamuraM.SondaS.et al (2012)

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If weight loss has plateaued at 2.4mg, a provider may evaluate whether a medication switch (e.g., to tirzepatide), dietary adjustment, or other intervention is appropriate rather than increasing the dose further

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