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In brief, SUs stimulate the release of insulin from the cells of the pancreatic islets via closure of the adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channel [18]

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When pretreating the cells with N -ethylmaleimide (NEM, 20 mM), a trapping reagent of thiol species, for 0.5 h, the signals from the cytoplasmic regions are decreased in both green and yellow channels (Figure 7DF)