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3 GLP-1R localization and mechanistic pathways in metabolic and behavioral regulation GLP-1 Rs exhibit high expression in pancreatic -cells in both rodents and humans, where they play a pivotal role in mediating glucose-dependent insulin secretion (Nauck et al., 1993

Chaves Filho AJM, Cunha NL, de Souza AG, Soares MVR, Juc PM, de Queiroz T, et al

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6 Overall Survival (OS): Data from MD Anderson Cancer Center showed that patients on GLP-1 RAs had a significantly higher median OS compared with controls (median not reached with GLP-1 RAs vs 24.1 years for control

These changes are likely both direct effects of the medications themselves on the hypothalamus in the brain and ovaries, says Dr