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hUC-MSCs improved ovarian function in CTX-induced POI mice by activating the nuclear-related factor-2 (Nrf-2) antioxidant pathway, enhancing iron metabolism (Nrf-2/ ferritin heavy chain 1(FTH1)), and promoting the antioxidant response (Nrf-2/ glutathione peroxidase 4 (GPX4)), thereby inhibiting ferroptosis [116]
The trade-offs are higher cost, aneesthesia, recovery time, and surgical risks
Total expected loss at month 12: 1522% of starting body weight depending on medication, lifestyle integration, and individual response
The standard protocol combines daily BPC-157 at 0.25 to 0.5 mg with TB-500 at 5 mg weekly during the loading phase, typically split into 2.5 mg doses twice weekly
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