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Notably, the authors suggested that semaglutide may reduce de novo collagen synthesis without causing degradation of pre-existing collagen fibers [29], implying that semaglutide may not improve existing fibrosis, but it may prevent the initiation and progression of fibrosis, which, however, needs other more focused studies to be definitively demonstrated

Glucagon-like peptide-1 (GLP-1) receptor agonists (e.g., semaglutide in Ozempic and Wegovy) and the dual GIP/GLP-1 receptor agonist tirzepatide (Mounjaro, Zepbound) work by mimicking naturally occurring hormones that regulate blood glucose and appetite