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Complementarily, IGF-1R preferentially activates IRS-2 [120] as it was found that IRS-2 contains a KLRB domain that functions to block the tyrosine kinase domain in the cytoplasmic region of the IR, and that such does not happen in the IGF-1R
PMCID: PMC7227109
From a pharmacovigilance perspective, phentermine shows fewer serious adverse events than several newer agents when prescribed as monotherapy
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