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Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)
Glutathione, biotin, and B-complex can be done weekly during a transformation series and monthly for maintenance
However, many people get full benefits without purging
But if you already have low blood pressure, its best to speak with your doctor before starting either, and especially if you plan to take them together