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Clinical studies and meta-analyses report significantly reduced circulating BDNF levels in patients with DR, particularly vision-threatening forms, compared with diabetic patients without retinopathy (238, 254)
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It is noteworthy that Pt-induced ROS production impairs antioxidant enzymes [e.g., superoxide dismutase (SOD) and catalase (CAT)] to trigger oxidative stress (Khasabova et al., 2019), which participates in the onset and progression of both acute and chronic PIPN
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