1,2 While the primary endpoint in the majority of clinical trials was mean change in A1C, mean change in body weight was generally evaluated as a confirmatory secondary endpoint
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Even though the activity of acarbose (IC 50 = 0.039 mg/mL) was stronger, all tested n-hexane extracts showed stronger -glucosidase inhibition (IC 50 = 0.03760.165 mg/mL) than acarbose (IC 50 = 4.69 mg/mL)
This binding triggers a cascade of effects: delayed gastric emptying, reduced glucagon secretion, enhanced insulin sensitivity, and most importantly for weight loss, decreased food intake through central appetite suppression (Wilding et al., NEJM, 2021)
Preliminary studies indicate that hydrogels can enhance cardiac regeneration and function without causing safety issues