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GantzIEronduNMallickMMusserBKrishnaRTanakaWKK.et al

PLoS One (2015) 10(5):e0126003

Mutations in both GLP1R and GIPR, a gene related to insulin secretion and energy production, were associated with nausea and vomiting

What happens to all those when the drug is stopped

Therefore, PEN2 plays a key role in the mechanism by which metformin enhances GLP-1 secretion
