Adherence is another major issue one study suggested that roughly two-thirds of patients discontinue GLP-1 therapy within the first year, often due to high costs, gastrointestinal side effects, lack of perceived benefit, or difficulty maintaining lifestyle changes
However, both Trulicity and tirzepatide have been criticized by patients and their surviving family members because of the pancreatitis, vision loss, and gastroparesis that these drugs have caused
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