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RG + CHF group demonstrated better renal protective effects than RG subgroup

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Blockade of the reninangiotensin system improves cerebral microcirculatory perfusion in diabetic hypertensive rats

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Remarkably, compromised mitochondrial function in ClpP IEC mice, as well as inhibition of mitochondrial respiration using oligomycin in murine and human organoid cultures was sufficient to reduce EEC marker gene expression, indicating a causative role for metabolism in steering differentiation into this IEC subtype

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Bibbiani F, Oh JD, Petzer JP, Castagnoli N Jr, Chen JF, Schwarzschild MA, et al

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These cytokines may cross the bloodbrain barrier, intensifying neurogenic inflammation in the brain

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