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This further supports the inverse relationship between mitochondrial ATP production and melanin, as adipose tissue contains melanin, and the adipose tissue of obese individuals contains more melanin than the adipose tissue of lean individuals (60), and it is known that there is mitochondrial dysfunction in the adipose tissue of obese individuals (61)

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Peripheral neuropathy can be secondary to disrupted cell signaling, loss of neurotrophic support, and structural alterations ( PET imaging studies on Alzheimers disease have shown that cognition has a better correlation with tau pathology than with A-plaque deposition (Shaw et al., 2009

By neutralizing lipid peroxides via the enzyme Glutathione Peroxidase 4 (GPx4), L-glutathione preserves the structural integrity of the mitochondrial membrane, allowing the ETC to resume efficient ATP production