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These effects are thought to be mediated by the neurotrophic actions of IGF-1, which crosses the blood-brain barrier and activates neuronal survival and synaptic plasticity pathways

However, serious adverse effects can occur, including pancreatitis (severe persistent abdominal pain), gallbladder disease, and acute kidney injury (typically related to dehydration from gastrointestinal symptoms)

Why this may happen: A high BMI is one lifestyle factor that can make it harder to get pregnant

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Reactive oxygen species as intracellular messengers during cell growth and differentiation