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The pharmacokinetics of sitagliptin was generally similar in healthy subjects and in patients with type 2 diabetes
Microbiota-driven changes in deconjugation and downstream transformation can modify the physicochemical properties of bile acids and their reabsorption in the distal ileum, thereby potentially affecting enterohepatic recycling and the relative availability of specific bile acid species within the intestinal lumen (82, 85, 86)
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