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Key hormones like GLP-1, leptin, ghrelin, and CCK act as crucial messengers, directly regulating the sensitivity and expression of peripheral taste receptors, while central neuromodulators, such as dopamine and serotonin, integrate these signals with reward and homeostatic circuits (172, 182)

(PubMed) Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ

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Thousands of patients almost gave up in Month 2