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Gastrointestinal effects likely contribute substantially to taste perception changes

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Considering a 20% dropout rate, the sample size will be inflated to 250 (approximately 63 per group) is required

The additional weight loss with bupropion/naltrexone was 4% to 5%

Multi-omics studies revealed that SARS-CoV-2 infection provokes significant changes in numerous metabolites including those impacting on virus propagation (one-carbon metabolism) and GSH synthesis (amino acids glutamic acid, cysteine and glycine) that could be used as early prognosis biomarkers in COVID-19 at diagnose to predict severe COVID-19 and LONG COVID (Doan et al., 2021