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The semaglutide group had a 24% lower risk of serious kidney problems or death from kidney disease, an 18% lower risk of cardiovascular diseases, and a 20% lower risk of death from any cause
The characteristics of the selected studies are provided in Tables 2 and 3
The most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipationsymptoms that can be particularly problematic in Parkinson's patients who often already experience autonomic dysfunction and gastroparesis
Upregulated humoral factors, such as Midkine, further promote tubulointerstitial injury by accelerating local NETosis and subsequent tubular cell death (220)
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