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For the non-acylated tirzepatideGLP-1Rmini-G s complex, the operations of the purification were the same as the peptide 20GLP-1RG s complex, except that the peptide was replaced by the non-acylated tirzepatide, and the detergent of SEC running buffer was changed to 0.01% digitonin

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GLP-1 RA use may also benefit patients who have metabolic dysfunction in preventing or slowing progression to cirrhosis, and its use in patients with cirrhosis has been associated with a decrease in all-cause mortality

In the normal glucose (NG) model, it enhanced glucose uptake by 30 and 50% at 500 g/mL and 1,000 g/mL, respectively, compared to 12% increase by 1,000 g/L PSK