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R Substrates glucuronidated by UGTs include: Acetaminophen (Tylenol) Bilirubin (heme degradation product) Estrogens (estradiol, estrone, estriol) Morphine and opioids NSAIDs (ibuprofen, naproxen) Thyroid hormones (T3, T4) There are four UGT families: UGT1A, UGT2A, UGT2B, and UGT3A
This flexibility enabled regulators to tailor safety monitoring based on actual risk profiles observed during drug development, facilitating the approval of drugs like GLP-1R agonists for broader therapeutic use, including in non-diabetic populations with Cardiovascular-Kidney-Metabolic (CKM) Syndrome
Medical necessity is documented through evaluations by healthcare providers
In addition, riboflavin can stimulate flavin-based extracellular electron transfer (FLEET) by Lactobacillaceae , as recently learned from Lactiplantibacillus plantarum and vegetable fermentations 209
