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While certain natural products have shown promising results in in vitro models, attributing them with specific therapeutic relevance, especially in in vivo ovarian reserve preservation, remains speculative without clearer mechanistic evidence (Supplementary Appendix 4)

Thus, ibuprofen is too hydrophilic to efficiently cross the BBB by passive diffusion

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It also costs almost nothing, and has been associated with many additional health benefits and overall reduction in all-cause mortality