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Grade 4 (life-threatening): Anaphylaxis, angioedema with airway compromise, or systemic urticaria

The encapsulation of DDA-GSH-AuNCs into PLGA nanoparticles does not alter the well documented biocompatibility of PLGA as evident from similar cellular viability of MCF-7 cells upon exposure to empty PLGA nanoparticles or PLGA nanoparticles encapsulating DDA-GSH-AuNCs in a wide range of nanoparticle concentration (4500 g/mL) as shown in Fig

Current opinion in pharmacology, 7(4), 355359

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Formal safety data specific to topical AHK-Cu is limited, and theoretical concerns such as copper accumulation with heavy long-term use have not been characterized in human studies