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The available data concerns low numbers of exposed pregnancies and lack a clear description of maternal and treatment characteristics with potential effect on neonatal outcome such as maternal BMI, drug dose and trimester of exposure

Methods Study design and data source This retrospective cohort study used de-identified electronic medical records from the TriNetX global federated research network, which aggregates data from more than 140 healthcare institutions across 19 countries

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Longer-duration orforglipron studies may close the gap, since GLP-1 weight loss typically continues beyond 40 weeks